Research in Vestibular Science

Autoimmune Inner Ear Disease Mimicking Bilateral Ménièreʼs Disease: A Case Report: Hong-Ju Kim, Yoon-Gi Choi, Hyun Ji Kim, Kyu-Sung Kim; Res Vestib Sci. 2018;17(1):28-34. Published online March 15, 2018; DOI: https://doi.org/10.21790/rvs.2018.17.1.28

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Autoimmune inner ear disease (AIED) is a rare disease, accounting for <1% of all cases of hearing impairment or dizziness. It is characterized by sensorineural hearing loss (SNHL) or vestibular dysfunction that results from an immunemediated process. Clinical features of AIED is SNHL that progresses over weeks to month with fluctuating hearing symptoms. Because there are no diagnostic laboratory and clinical feature, response to immunosuppressive therapy were important for diagnosis of AIED. Many diseases such as sudden SNHL and Meniere disease may also mimic AIED, a broad differential must be maintained in patients suspected of having AIED. We report a case of a 46-year-old female who presented with sudden hearing loss and vertigo. We could diagnose her as AIED with systemic lupus erythematous. The symptoms were improved treated with steroids.

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Sensorineural Hearing Loss of Suspected Autoimmune Etiology: Two Cases of Cogan’s Syndrome
Jungmin Ahn, Brian Kim, Kyoung Rai Cho, Young-Soo Chang
Korean Journal of Otorhinolaryngology-Head and Nec.2021; 64(12): 943. CrossRef
A Case of Autoimmune Sensorineural Hearing Loss Responding to Cytotoxic Agent
Yong Woo Lee, Jin Lee, Min-Beom Kim, Sun O Chang
Korean Journal of Otorhinolaryngology-Head and Nec.2019; 62(8): 470. CrossRef

Usefulness Assessment of Cochlear Hydrops Analysis Masking Procedure Test in Progress of Ménièreʼs Disease: Young-Joo Ko, Hyun Ji Kim, Dae-Young Kim, Tae-Suk Kyung, Kyu-Sung Kim; Res Vestib Sci. 2017;16(1):17-22. Published online March 15, 2017; DOI: https://doi.org/10.21790/rvs.2017.16.1.17

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Abstract PDF: Objective: There were few recent study concern about usefulness of cochlear hydrops analysis masking procedure (CHAMP) in progression of Ménièreʼs disease. The purpose of this study is to analyze changes in the CHAMP as advancement of Ménièreʼs disease.
Methods
We studied 19 cases of ‘Definite’ group of Ménièreʼs disease. We assumed progression of Ménièreʼs disease would be checked by pure tone threshold by four tone average (4PTA), low tone average (LPTA). We also compared electrocochleography (ECoG), dizziness handicap inventory (DHI), tinnitus handicap inventory (THI) as parameters for progression of Ménièreʼs disease to CHAMP latency delay and amplitude ratio. Chi-square test was used as a statistical method.
Results
In the group of patients had abnormal amplitude ratio, ECoG value were not improved, but there was not statistically significant (odds ratio [OR]=5.727, p＞0.05). Better DHI and THI score were not necessarily construed as the improvement value in the CHAMP (p＞0.05). In amplitude ratio abnormal group, 4PTA was aggravated, but not statistically significant (OR=1.5, p＞0.05). In the group of patient had abnormality in both latency delay and amplitude ratio, LPTA was relatively aggravated (OR in latency delay: 2, OR in amplitude ratio: 10); however, reveals no statistically significance between them (p＞0.05). Change of ECoG, hearing threshold including 4PTA and LPTA with progression of Ménièreʼs disease were not correlated significantly with latency delay or amplitude ratio of CHAMP.
Conclusion
We conclude that CHAMP does not reflect clinical features with progression of Ménièreʼs disease.

A History for Experimental Animal Models of Endolymphatic Hydrops: Hyun Ji Kim, Kyu-Sung Kim; Res Vestib Sci. 2016;15(3):65-69. Published online September 15, 2016; DOI: https://doi.org/10.21790/rvs.2016.15.3.65

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Abstract PDF: It is known that endolymphatic hydrops is a pathophysiologic mechanism of Meniere’s disease, while the detailed role is not fully clarified. Study for endolymphatic hydrops mainly represents a pathologic histologic finding found only in the post-mortem examination of temporal bone, so endolymphatic hydrops animal models have played important role in terms of understanding how hydrops affects the function of the inner ear. Numerous challenges with diverse animals and techniques have been tried to reveal the possible pathophysiology of endolymphatic hydrops and develop an effective treatment. This review shows historical background and technical advances in experimental animal model for endolymphatic hydrops and Meniere’s disease.

Updates in Intractable Benign Paroxysmal Positioning Vertigo: Yoon Gi Choi, Young Joo Ko, Hyun Ji Kim, Kyu Sung Kim; Res Vestib Sci. 2016;15(2):39-43. Published online June 15, 2016

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Abstract PDF: Benign paroxysmal positioning vertigo (BPPV) is the most common disease that causes dizziness which is usually resolved spontaneously or by office-based physical therapy. However, clinicians sometimes encounter atypical or intractable BPPV cases which show poor effect with physical therapy including canalith reposition therapy and liberative maneuvers and frequent recurrence. There is no common definition, diagnosis and treatment protocols for intractable BPPV. Various types of intractable BPPV and reported treatment methods are discussed in this review.

Use of Parabolic Flight for the Research of Aerospace Biomedicine: Young Hyo Kim, Joo Hee Lee, Chang Kyung Ryoo, Hyun Ji Kim, Kyu Sung Kim; Res Vestib Sci. 2015;14(2):42-45.

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Abstract PDF: As it is difficult to perform biological study in the actual space, several researchers have tried to develop methods that could ‘mimic’ microgravity condition on Earth. During the free fall of the aircraft, so-called ‘parabolic flight’, objects in a plane could experience weightlessness during a short period of time (approximately 20 to 30 seconds). We first reviewed former studies using parabolic flight in a variety of research filed including vestibular, neurologic, cardiovascular, musculoskeletal and immune system. We also investigated the actual conditions of biologic research using parabolic flight in Korea, by performing a questionnaire survey for 19 experts in space biology.

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